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clinmed/2003010004v1 (February 13, 2003)
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LYELL’S SYNDROME AND CLARITHROMYCIN

Nadia Khaldi, Koffi Botti, Antoine Oliveira, and Sophie Gromb

Lyell’s syndrome almost always occurs after taking medication and mortality is high, particularly due to infectious complications. Despite spectacular clinical signs, it is mainly diagnosed with pathologic techniques. The involvement of a drug as sole cause of such an allergic reaction must be demonstrated, especially since the molecule incriminated is not generally known to be a classical cause of this reaction. The imputability is based on a number of clinical arguments. The present study describes a female patient who rapidly developed an extensive bullous toxidermia after taking clarithromycin for tonsillitis. The case illustrates the process involved in attributing imputability to a molecule.




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